She is unlocked upon surviving 20 minutes with at least 10% Curse active. She needs to be purchased for 500, which scales with other characters purchased.
The actual condition for the achievement is to have any amount of Curse higher than the base value by the end of the run and in the same run survive at least 20 minutes. This means unlocking Lama can be also be achieved - besides the use of the Curse PowerUp - by obtaining Curse from Golden Eggs or passive items that grant Curse, such as Skull O'Maniac, Gold Ring (level 2+), Metaglio Right (level 2+) or Torrona's Box (level 9), either through level ups or picking them up as stage items. Due to the loose criteria, you also do not have to have the item for full 20 minute duration, but only have it by the conclusion of a 20+ minute run.
The following table shows how much Might, MoveSpeed and Curse she gains by level:
- Lama's complete name is Lama Ladonna, which is likely derived from "La Madonna", an exclamation of surprise in Italian.
- "Lama" also translates to "blade" in Italian, this might be in reference to the fact she wields an axe.
- Lama at level 40 is the second fastest character alongside Krochi and Christine, behind Red Death.